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Brake and gas pedals in motor cortex

Nature Neuroscience volume 20, pages 4–6 (2017)Cite this article

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A new study finds that a major population of output cells in primary motor cortex suppresses movement and behavioral engagement.

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Figure 1: Pathways in vM1 for promotion and suppression of motor engagement.

Katie Vicari/Nature Publishing Group

References

  1. Sasaki, K., Gemba, H. & Tsujimoto, T. Brain Res. 495, 100–107 (1989).

    Article  CAS  Google Scholar 

  2. Chambers, C.D., Garavan, H. & Bellgrove, M.A. Neurosci. Biobehav. Rev. 33, 631–646 (2009).

    Article  Google Scholar 

  3. Coxon, J.P., Stinear, C.M. & Byblow, W.D. J. Neurophysiol. 95, 3371–3383 (2006).

    Article  Google Scholar 

  4. Ebbesen, C.L., Doron, G., Lenschow, C. & Brecht, M. Nat. Neurosci. 20, 82–89 (2017).

    Article  CAS  Google Scholar 

  5. Hill, D.N., Curtis, J.C., Moore, J.D. & Kleinfeld, D. Neuron 72, 344–356 (2011).

    Article  CAS  Google Scholar 

  6. Brecht, M., Schneider, M., Sakmann, B. & Margrie, T.W. Nature 427, 704–710 (2004).

    Article  CAS  Google Scholar 

  7. Haiss, F. & Schwarz, C. J. Neurosci. 25, 1579–1587 (2005).

    Article  CAS  Google Scholar 

  8. Matyas, F. et al. Science 330, 1240–1243 (2010).

    Article  CAS  Google Scholar 

  9. Mao, T. et al. Neuron 72, 111–123 (2011).

    Article  CAS  Google Scholar 

  10. Guo, J.Z. et al. eLife 4, e10774 (2015).

    Article  Google Scholar 

  11. Georgopoulos, A.P., Schwartz, A.B. & Kettner, R.E. Science 233, 1416–1419 (1986).

    Article  CAS  Google Scholar 

  12. Graziano, M.S., Taylor, C.S. & Moore, T. Neuron 34, 841–851 (2002).

    Article  CAS  Google Scholar 

  13. Zagha, E., Ge, X. & McCormick, D.A. Neuron 88, 565–577 (2015).

    Article  CAS  Google Scholar 

  14. Hill, D.N., Bermejo, R., Zeigler, H.P. & Kleinfeld, D. J. Neurosci. 28, 3438–3455 (2008).

    Article  CAS  Google Scholar 

  15. Chakrabarti, S. & Schwarz, C. in Sensorimotor Integration in the Whisker System (ed. P. Krieger & A. Groh) 129–148 (Springer New York, 2015).

    Book  Google Scholar 

Download references

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Authors and Affiliations

  1. Jinho Kim and S. Andrew Hires are in the Department of Biological Sciences, Section of Neurobiology, University of Southern California, Los Angeles, California, USA.,

    Jinho Kim & S Andrew Hires

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  1. Jinho Kim
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  2. S Andrew Hires
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Correspondence to S Andrew Hires.

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Kim, J., Hires, S. Brake and gas pedals in motor cortex. Nat Neurosci 20, 4–6 (2017). https://doi.org/10.1038/nn.4461

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