Q&A | Published:

Viewpoints: Dialogues on the functional role of the ventromedial prefrontal cortex

Nature Neuroscience volume 19, pages 15451552 (2016) | Download Citation

The ventromedial prefrontal cortex is attributed with various functions during valuation, affect regulation and social cognition. Nature Neuroscience asked a moderator to lead researchers in a dialogue on shared and distinct viewpoints of this region's roles.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    et al. J. Neurosci. 30, 2490–2495 (2010).

  2. 2.

    , , & Neuron 43, 897–905 (2004).

  3. 3.

    , , & Neuroimage 58, 275–285 (2011).

  4. 4.

    , & Neuron 90, 692–707 (2016).

  5. 5.

    , , , & Cereb. Cortex 14, 647–654 (2004).

  6. 6.

    , & Neurosci. Biobehav. Rev. 36, 1043–1059 (2012).

  7. 7.

    & Front. Hum. Neurosci. 7, 450 (2013).

  8. 8.

    & J. Cogn. Neurosci. 25, 613–622 (2013).

  9. 9.

    & Neuroimage 61, 889–898 (2012).

  10. 10.

    , & Neuroimage 76, 412–427 (2013).

  11. 11.

    et al. J. Neurosci. 35, 2308–2320 (2015).

  12. 12.

    , & Science 324, 646–648 (2009).

  13. 13.

    , & Neuropsychologia 50, 1536–1542 (2012).

  14. 14.

    Brain 129, 944–952 (2006).

  15. 15.

    , & J. Neurosci. 30, 16868–16875 (2010).

  16. 16.

    , , & Eur. J. Neurosci. 35, 997–1010 (2012).

  17. 17.

    , & Biol. Psychiatry 60, 329–336 (2006).

  18. 18.

    & Annu. Rev. Psychol. 63, 129–151 (2012).

  19. 19.

    & Eur. J. Neurosci. 25, 2498–2503 (2007).

  20. 20.

    , & Learn. Mem. 16, 279–288 (2009).

  21. 21.

    et al. J. Neurosci. 33, 18225–18233 (2013).

  22. 22.

    , , , & J. Neurosci. 34, 9736–9742 (2014).

  23. 23.

    , , & Behav. Brain Res. 232, 210–216 (2012).

  24. 24.

    & Trends Cogn. Sci. 14, 268–276 (2010).

  25. 25.

    , , & J. Neurosci. 34, 14733–14738 (2014).

  26. 26.

    et al. Biol. Psychiatry 66, 1075–1082 (2009).

  27. 27.

    , & J. Cogn. Neurosci. 17, 1306–1315 (2005).

  28. 28.

    et al. Proc. Natl. Acad. Sci. USA 110 Suppl 2, 10387–10394 (2013).

  29. 29.

    , , & Science 313, 1310–1312 (2006).

  30. 30.

    , & , J. Curr. Opin. Neurobiol. 23, 436–442 (2013).

  31. 31.

    , & Nat. Neurosci. 16, 243–250 (2013).

  32. 32.

    & Curr. Opin. Behav. Sci. 1, 1–8 (2015).

  33. 33.

    & Nat. Commun. (2015).

  34. 34.

    et al. Nat. Neurosci. 16, 270–272 (2013).

  35. 35.

    & J. Cogn. Neurosci. 14, 709–720 (2002).

  36. 36.

    et al. Sci. Adv. 1, e1500251 (2015).

  37. 37.

    , , , & J. Neurosci. 35, 3607–3615 (2015).

  38. 38.

    & Trends Neurosci. 39, 340–351 (2016).

  39. 39.

    & Curr. Opin. Neurobiol. 22, 1027–1038 (2012).

  40. 40.

    & Nat. Rev. Neurosci. 15, 549–562 (2014).

  41. 41.

    et al. J. Neurosci. 33, 11032–11039 (2013).

  42. 42.

    , & Nat. Neurosci. 18, 620–627 (2015).

  43. 43.

    , , & J. Neurosci. 35, 8507–8514 (2015).

  44. 44.

    , , & Science 275, 1293–1295 (1997).

  45. 45.

    , , , & eNeuro (2015).

  46. 46.

    & Trends Cogn. Sci. 13, 524–531 (2009).

  47. 47.

    , , & Soc. Cogn. Affect. Neurosci. 1, 49–55 (2006).

  48. 48.

    & Curr. Biol. 22, 2268–2273 (2012).

  49. 49.

    & Neuropsychologia 48, 3377–3391 (2010).

  50. 50.

    , & Science 324, 948–950 (2009).

  51. 51.

    et al. Nat. Neurosci. 8, 365–371 (2005).

  52. 52.

    , , , & Neurobiol. Learn. Mem. 113, 149–156 (2014).

  53. 53.

    & Brain Res. 1355, 52–60 (2010).

  54. 54.

    , & Eur. J. Neurosci. 26, 3606–3613 (2007).

  55. 55.

    , , , & Psychol. Sci. 24, 2182–2190 (2013).

  56. 56.

    , , & Soc. Cogn. Affect. Neurosci. 11, 1541–1549 (2016).

  57. 57.

    & Nat. Neurosci. 10, 1625–1633 (2007).

  58. 58.

    , & Neuron 80, 1491–1507 (2013).

  59. 59.

    , , , & Cell Reports 10, 1435–1442 (2015).

  60. 60.

    et al. Nature 527, 179–185 (2015).

  61. 61.

    et al. Neuron 81, 428–437 (2014).

  62. 62.

    , & Nat. Neurosci. 13, 489–494 (2010).

  63. 63.

    , , , & Nature 412, 150–157 (2001).

  64. 64.

    & Annu. Rev. Physiol. 66, 735–769 (2004).

  65. 65.

    & Nature 457, 475–479 (2009).

  66. 66.

    & Cereb. Cortex 20, 404–410 (2010).

  67. 67.

    & Neuroimage 83, 599–608 (2013).

  68. 68.

    , , , & Biol. Psychiatry 80, 509–521 (2016).

  69. 69.

    , & Soc. Cogn. Affect. Neurosci. 7, 274–281 (2012).

  70. 70.

    , & Trends Cogn. Sci. 16, 147–156 (2012).

  71. 71.

    , & Neuron 82, 950–965 (2014).

Download references

Author information

Affiliations

  1. Mauricio R. Delgado is in the Department of Psychology, Rutgers University, Newark, New Jersey, USA.

    • Mauricio R Delgado
  2. Jennifer S. Beer is in the Department of Psychology, University of Texas at Austin, Austin, Texas, USA.

    • Jennifer S Beer
  3. Lesley K. Fellows is in the Department of Neurology & Neurosurgery, McGill University, Montreal, Canada.

    • Lesley K Fellows
  4. Scott A. Huettel is in the Department of Psychology & Neuroscience, Duke University, Durham, North Carolina, USA.

    • Scott A Huettel
  5. Michael L. Platt is in the Department of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

    • Michael L Platt
  6. Gregory J. Quirk is in the Departments of Psychiatry and Anatomy & Neurobiology, University of Puerto Rico, San Juan, Puerto Rico, USA.

    • Gregory J Quirk
  7. Daniela Schiller is in the Departments of Psychiatry and Neuroscience and the Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

    • Daniela Schiller

Authors

  1. Search for Mauricio R Delgado in:

  2. Search for Jennifer S Beer in:

  3. Search for Lesley K Fellows in:

  4. Search for Scott A Huettel in:

  5. Search for Michael L Platt in:

  6. Search for Gregory J Quirk in:

  7. Search for Daniela Schiller in:

Supplementary information

PDF files

  1. 1.

    Supplementary Note 1

    A brief anatomical sketch of human ventromedial prefrontal cortex

  2. 2.

    Supplementary Note 2

    VmPFC function: the value proposition

  3. 3.

    Supplementary Note 3

    The affective regulation perspective of vmPFC function

  4. 4.

    Supplementary Note 4

    An overview of human and animal research on the social cognitive function of the ventromedial prefrontal cortex

  5. 5.

    Supplementary Note 5

    VIEWPOINTS: Dialogues on the functional role of the ventromedial prefrontal cortex (UNABRIDGED)

About this article

Publication history

Published

DOI

https://doi.org/10.1038/nn.4438

Further reading

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing