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When size matters: CHD8 in autism

Recent models studying loss of the mouse homolog of the autism-associated gene CHD8 show altered Wnt signaling, cell fate and proliferation. How do these findings shape our understanding of this disease?

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Figure 1: Schematic overview of the genetic origin and functional impact of Chd8 and CHD8 loss in the paper by Durak et al.2 (left column), human subjects (middle column)14 and the paper by Katayama et al.3 (right column).

References

  1. Cotney, J. et al. Nat. Commun. 6, 6404 (2015).

    Article  CAS  Google Scholar 

  2. Durak, O. et al. Nat. Neurosci. 1477–1488 (2016).

  3. Katayama, Y. et al. Nature 537, 675–679 (2016).

    Article  CAS  Google Scholar 

  4. Thompson, B.A., Tremblay, V., Lin, G. & Bochar, D.A. Mol. Cell. Biol. 28, 3894–3904 (2008).

    Article  CAS  Google Scholar 

  5. Marchetto, M.C. et al. Mol. Psychiatry http://dx.doi.org/10.1038/mp.2016.95 (2016).

  6. Arai, Y. et al. Nat. Commun. 2, 154 (2011).

    Article  Google Scholar 

  7. Redcay, E. & Courchesne, E. Biol. Psychiatry 58, 1–9 (2005).

    Article  Google Scholar 

  8. Huguet, G., Ey, E. & Bourgeron, T. Annu. Rev. Genomics Hum. Genet. 14, 191–213 (2013).

    Article  CAS  Google Scholar 

  9. Robinson, E.B. et al. Proc. Natl. Acad. Sci. USA 111, 15161–15165 (2014).

    Article  CAS  Google Scholar 

  10. Haar, S., Berman, S., Behrmann, M. & Dinstein, I. Cereb. Cortex 26, 1440–1452 (2016).

    Article  Google Scholar 

  11. Sparks, B.F. et al. Neurology 59, 184–192 (2002).

    Article  CAS  Google Scholar 

  12. Robinson, E.B. et al. Nat. Genet. 48, 552–555 (2016).

    Article  CAS  Google Scholar 

  13. Berg, J.M. & Geschwind, D.H. Genome Biol. 13, 247 (2012).

    Article  Google Scholar 

  14. Bernier, R. et al. Cell 158, 263–276 (2014).

    Article  CAS  Google Scholar 

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Correspondence to Joseph G Gleeson.

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Breuss, M., Gleeson, J. When size matters: CHD8 in autism. Nat Neurosci 19, 1430–1432 (2016). https://doi.org/10.1038/nn.4431

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