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When size matters: CHD8 in autism

Recent models studying loss of the mouse homolog of the autism-associated gene CHD8 show altered Wnt signaling, cell fate and proliferation. How do these findings shape our understanding of this disease?

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Figure 1: Schematic overview of the genetic origin and functional impact of Chd8 and CHD8 loss in the paper by Durak et al.2 (left column), human subjects (middle column)14 and the paper by Katayama et al.3 (right column).


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Correspondence to Joseph G Gleeson.

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Breuss, M., Gleeson, J. When size matters: CHD8 in autism. Nat Neurosci 19, 1430–1432 (2016).

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