Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Rare variants are common in schizophrenia

Nature Neuroscience volume 19, pages 1426–1428 (2016)Cite this article

Subjects

A large DNA sequencing study of schizophrenia finds more evidence that rare inherited coding mutations across many genes contribute to risk of the disorder. This has important implications for geneticists and neuroscientists alike.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Whole-exome sequencing studies of schizophrenia in the context of recent milestones in schizophrenia genetics.

References

  1. Schizophrenia Working Group of the Psychiatric Genomics Consortium. Nature 511, 421–427 (2014).

  2. Fromer, M. et al. Nature 506, 179–184 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Levinson, D.F. et al. Am. J. Psychiatry 168, 302–316 (2011).

    Article  PubMed  PubMed Central  Google Scholar 

  4. O'Donovan, M.C. et al. Nat. Genet. 40, 1053–1055 (2008).

    Article  CAS  PubMed  Google Scholar 

  5. Purcell, S.M. et al. Nature 506, 185–190 (2014).

    CAS  PubMed  PubMed Central  Google Scholar 

  6. Purcell, S.M. et al. Nature 460, 748–752 (2009).

    Article  CAS  PubMed  Google Scholar 

  7. Ripke, S. et al. Nat. Genet. 45, 1150–1159 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium Nat. Genet. 43, 969–976 (2011).

  9. Singh, T. et al. Nat. Neurosci. 19, 571–577 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Stefansson, H. et al. Nature 460, 744–747 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Walsh, T. et al. Science 320, 539–543 (2008).

    Article  CAS  PubMed  Google Scholar 

  12. Xu, B. et al. Nat. Genet. 43, 864–868 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Genovese, G. et al. Nat. Neurosci. 19, 1433–1441 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Power, R.A. et al. JAMA Psychiatry 70, 22–30 (2013).

    Article  PubMed  Google Scholar 

  15. Sullivan, P.F., Kendler, K.S. & Neale, M.C. Arch. Gen. Psychiatry 60, 1187–1192 (2003).

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Jacob Gratten is in the Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.,

    Jacob Gratten

Authors
  1. Jacob Gratten
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jacob Gratten.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Gratten, J. Rare variants are common in schizophrenia. Nat Neurosci 19, 1426–1428 (2016). https://doi.org/10.1038/nn.4422

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nn.4422

This article is cited by

Search

Advanced search

Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research