Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Life and death rest on a bivalent chromatin state

Neurons require lifelong maintenance of their transcriptional program, which includes stable expression of cell-type-specific identity genes. A study now shows that PRC2-mediated chromatin repression in adulthood is critical for the maintenance of neuronal identity gene expression and neuronal survival.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: The PRC2 complex includes histone H3K27 methyltransferase Ezh1 or Ezh2, along with several other protein subunits3.

References

  1. 1

    Deneris, E.S. & Hobert, O. Nat. Neurosci. 17, 899–907 (2014).

    CAS  Article  Google Scholar 

  2. 2

    von Schimmelmann, M. et al. Nat. Neurosci. 19, 1321–1330 (2016).

    CAS  Article  Google Scholar 

  3. 3

    Margueron, R. & Reinberg, D. Nature 469, 343–349 (2011).

    CAS  Article  Google Scholar 

  4. 4

    Lee, T.I. et al. Cell 125, 301–313 (2006).

    CAS  Article  Google Scholar 

  5. 5

    Shen, X. et al. Mol. Cell 32, 491–502 (2008).

    CAS  Article  Google Scholar 

  6. 6

    Bernstein, B.E. et al. Cell 125, 315–326 (2006).

    CAS  Article  Google Scholar 

  7. 7

    Mikkelsen, T.S. et al. Nature 448, 553–560 (2007).

    CAS  Article  Google Scholar 

  8. 8

    Jadhav, U. et al. Cell 165, 1389–1400 (2016).

    CAS  Article  Google Scholar 

  9. 9

    Crook, Z.R. & Housman, D. Neuron 69, 423–435 (2011).

    CAS  Article  Google Scholar 

  10. 10

    Raymond, L.A. et al. Neuroscience 198, 252–273 (2011).

    CAS  Article  Google Scholar 

  11. 11

    Lu, X.H. et al. Sci. Transl. Med. 6, 268ra178 (2014).

    Article  Google Scholar 

  12. 12

    Parrish, J.Z., Emoto, K., Jan, L.Y. & Jan, Y.N. Genes Dev. 21, 956–972 (2007).

    CAS  Article  Google Scholar 

  13. 13

    Baker, D.J. et al. Nature 530, 184–189 (2016).

    CAS  Article  Google Scholar 

  14. 14

    Seong, I.S. et al. Hum. Mol. Genet. 19, 573–583 (2010).

    CAS  Article  Google Scholar 

  15. 15

    Langfelder, P. et al. Nat. Neurosci. 19, 623–633 (2016).

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to X William Yang.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Yang, X. Life and death rest on a bivalent chromatin state. Nat Neurosci 19, 1271–1273 (2016). https://doi.org/10.1038/nn.4396

Download citation

Further reading

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing