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Crash course in pallidus–habenula signaling

During cocaine withdrawal, a shift in the balance between excitatory and inhibitory inputs from globus pallidus to lateral habenula may activate habenula and contribute to the aversive 'crash' state.

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Figure 1: Shift in balance between inhibitory and excitatory input from pallidum to habenula during cocaine withdrawal.

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Correspondence to Paul J Kenny.

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Ishikawa, M., Kenny, P. Crash course in pallidus–habenula signaling. Nat Neurosci 19, 981–983 (2016). https://doi.org/10.1038/nn.4349

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