How (not) to silence long-range projections with light

Inhibitory optogenetic tools prevent action potential generation during illumination. A study explores the possibility of squelching already propagating action potentials locally at axon terminals before they trigger neurotransmitter release.

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Figure 1: Optogenetic inhibition works well at the soma but can have unexpected effects when presynaptic terminals are illuminated.

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Correspondence to Thomas G Oertner.

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Wiegert, J., Oertner, T. How (not) to silence long-range projections with light. Nat Neurosci 19, 527–528 (2016) doi:10.1038/nn.4270

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