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Novel domain formation reveals proto-architecture in inferotemporal cortex

Nature Neuroscience volume 17, pages 17761783 (2014) | Download Citation

Abstract

Primate inferotemporal cortex is subdivided into domains for biologically important categories, such as faces, bodies and scenes, as well as domains for culturally entrained categories, such as text or buildings. These domains are in stereotyped locations in most humans and monkeys. To ask what determines the locations of such domains, we intensively trained seven juvenile monkeys to recognize three distinct sets of shapes. After training, the monkeys developed regions that were selectively responsive to each trained set. The location of each specialization was similar across monkeys, despite differences in training order. This indicates that the location of training effects does not depend on function or expertise, but rather on some kind of proto-organization. We explore the possibility that this proto-organization is retinotopic or shape-based.

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Acknowledgements

T. Savage trained the monkeys and helped with scanning. This work was supported by US National Institutes of Health (NIH) grants EY 16187 and EY 24187, and the Nancy Lurie Marks Foundation. This research was carried out in part at the Athinoula A. Martinos Center for Biomedical Imaging at the Massachusetts General Hospital, using resources provided by the Center for Functional Neuroimaging Technologies, P41EB015896, a P41 Biotechnology Resource Grant supported by the US National Institute of Biomedical Imaging and Bioengineering, NIH, and NIH Shared Instrumentation Grant S10RR021110.

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Affiliations

  1. Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, USA.

    • Krishna Srihasam
    • , Justin L Vincent
    •  & Margaret S Livingstone

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Contributions

M.S.L. did the behavioral experiments. K.S., J.L.V. and M.S.L. did the scanning. K.S. analyzed the data. M.S.L. wrote the manuscript.

Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Margaret S Livingstone.

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DOI

https://doi.org/10.1038/nn.3855

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