The Top3β way to untangle RNA

With evidence from model organisms and human population genetic analysis, two studies in this issue report discoveries that eukaryotic Top3β has RNA topoisomerase activity and, in a ribonucleoprotein complex with FMRP, is important for neurodevelopment and normal cognition.

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Figure 1: Top3β is an RNA topoisomerase that, together with FMRP, is important for neurodevelopment.

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Correspondence to Li-Huei Tsai.

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Nott, A., Tsai, L. The Top3β way to untangle RNA. Nat Neurosci 16, 1163–1164 (2013) doi:10.1038/nn.3506

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