Dopamine signals mimic reward prediction errors

An Erratum to this article was published on 21 November 2014

This article has been updated

Modern theories of associative learning center on a prediction error. A study finds that artificial activation of dopamine neurons can substitute for missing reward prediction errors to rescue blocked learning.

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Figure 1: Prediction errors and blocking.

Katie Vicari

Change history

  • 01 July 2013

    In the version of this article initially published, Mihaela D. Iordanova's affiliation was given as the Department of Psychology, University of Maryland Baltimore County instead of the Department of Anatomy and Neurobiology, University of Maryland, School of Medicine, and the former was omitted from Geoffrey Schoenbaum's affiliations. The error has been corrected in the HTML and PDF versions of the article.


  1. 1

    Rescorla, R.A. & Wagner, A.R. in Classical Conditioning II: Current Research and Theory (eds. Black, A.H. & Prokasy, W.F.) 64–99 (Appleton-Century-Crofts, New York, 1972).

    Google Scholar 

  2. 2

    Pearce, J.M. & Hall, G. Psychol. Rev. 87, 532–552 (1980).

    CAS  Article  Google Scholar 

  3. 3

    Sutton, R.S. & Barto, A.G. Psychol. Rev. 88, 135–170 (1981).

    CAS  Article  Google Scholar 

  4. 4

    Steinberg, E.E. et al. Nat. Neurosci. 16, 966–973 (2013).

    CAS  Article  Google Scholar 

  5. 5

    Schultz, W., Dayan, P. & Montague, P.R. Science 275, 1593–1599 (1997).

    CAS  Article  Google Scholar 

  6. 6

    Mirenowicz, J. & Schultz, W. J. Neurophysiol. 72, 1024–1027 (1994).

    CAS  Article  Google Scholar 

  7. 7

    Takahashi, Y.K. et al. Neuron 62, 269–280 (2009).

    CAS  Article  Google Scholar 

  8. 8

    Iordanova, M.D., Westbrook, R.F. & Killcross, A.S. Eur. J. Neurosci. 24, 3265–3270 (2006).

    Article  Google Scholar 

  9. 9

    Darvas, M. & Palmiter, R.D. Proc. Natl. Acad. Sci. USA 106, 14664–14669 (2009).

    CAS  Article  Google Scholar 

  10. 10

    Tsai, H.C. et al. Science 324, 1080–1084 (2009).

    CAS  Article  Google Scholar 

  11. 11

    Adamantidis, A.R. et al. J. Neurosci. 31, 10829–10835 (2011).

    CAS  Article  Google Scholar 

  12. 12

    Razran, G. Psychol. Bull. 63, 42–64 (1965).

    CAS  Article  Google Scholar 

  13. 13

    Kamin, L.J. in Punishment and Aversive Behavior (eds. Campbell, B.A. & Church, R.M.) 242–259 (Appleton-Century-Crofts, New York, 1969).

    Google Scholar 

  14. 14

    Waelti, P., Dickinson, A. & Schultz, W. Nature 412, 43–48 (2001).

    CAS  Article  Google Scholar 

  15. 15

    Matsumoto, M. & Hikosaka, O. Nature 459, 837–841 (2009).

    CAS  Article  Google Scholar 

Download references

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Correspondence to Geoffrey Schoenbaum.

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Schoenbaum, G., Esber, G. & Iordanova, M. Dopamine signals mimic reward prediction errors. Nat Neurosci 16, 777–779 (2013).

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