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Convergent cortical innervation of striatal projection neurons

Nature Neuroscience volume 16, pages 665667 (2013) | Download Citation

Abstract

Anatomical studies have led to the assertion that intratelencephalic and pyramidal tract cortical neurons innervate different striatal projection neurons. To test this hypothesis, we measured the responses of mouse striatal neurons to optogenetic activation of intratelencephalic and pyramidal tract axons. Contrary to expectation, direct and indirect pathway striatal spiny projection neurons responded to both intratelencephalic and pyramidal tract activation, arguing that these cortical networks innervate both striatal projection neurons.

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References

  1. 1.

    , , & Science 265, 1826–1831 (1994).

  2. 2.

    & Annu. Rev. Neurosci. 34, 441–466 (2011).

  3. 3.

    & Handbook of Basal Ganglia Structure and Function (eds. Steiner, H. & Tseng, K.Y.) 3–28 (Elsevier/Academic Press, Amsterdam, 2010).

  4. 4.

    , & Trends Neurosci. 12, 366–375 (1989).

  5. 5.

    , , & J. Neurosci. 24, 8289–8299 (2004).

  6. 6.

    et al. J. Comp. Neurol. 457, 420–440 (2003).

  7. 7.

    , , & Front. Neuroanat. 4, 142 (2010).

  8. 8.

    , , & Trends Neurosci. 35, 457–467 (2012).

  9. 9.

    et al. Eur. J. Neurosci. 27, 2313–2321 (2008).

  10. 10.

    Nat. Rev. Neurosci. 2, 861–870 (2001).

  11. 11.

    , , & J. Neurosci. 32, 7021–7033 (2012).

  12. 12.

    , , & J. Neurosci. 32, 4992–5001 (2012).

  13. 13.

    , & Nat. Protoc. 5, 595–606 (2010).

  14. 14.

    J. Comp. Neurol. 263, 567–580 (1987).

  15. 15.

    Nat. Rev. Neurosci. 14, 278–291 (2013).

  16. 16.

    et al. Nature 494, 238–242 (2013).

  17. 17.

    et al. Front. Neural Circuits 4, 100 (2010).

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Acknowledgements

We thank S. Ulrich, K. Saporito, Y. Chen and L. Fisher for animal husbandry and genotyping, as well as members of the Shepherd and Surmeier laboratories for helpful discussions. We thank H.S. Seung (Massachusetts Institute of Technology) for providing the virus. This work is supported by grants from the National Institute of Neurological Disorders and Stroke (T32NS041234 to G.J.K., R01NS034696 to D.J. S., R01NS061963 to G.M.G.S. and P30NS054850 to D.L.W.), the CHDI Foundation and the JPB Foundation.

Author information

Affiliations

  1. Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.

    • Geraldine J Kress
    • , Naoki Yamawaki
    • , David L Wokosin
    • , Gordon M G Shepherd
    •  & D James Surmeier
  2. Media Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

    • Ian R Wickersham

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Contributions

G.J.K. conducted the experiments, injections, data analysis and imaging. N.Y. performed injections and imaging. D.L.W. provided technical expertise with all aspects of the photoactivation system. I.R.W. provided rabies virus technical assistance. D.J.S. supervised the project. G.J.K., G.M.G.S., N.Y. and D.J.S. designed the experiments. G.J.K. and D.J.S. prepared the manuscript.

Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to D James Surmeier.

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DOI

https://doi.org/10.1038/nn.3397

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