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NUB1 snubs huntingtin toxicity

Nature Neuroscience volume 16, pages 523–525 (2013)Cite this article

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A screen now identifies a protein that regulates degradation of mutant huntingtin, which causes Huntington's disease, and manipulations show that promoting clearance of the toxic protein itself may be sufficient to halt disease.

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Figure 1: Potential mechanism of NUB1-mediated mHTT degradation and suppression of toxicity.

References

  1. Lu, B. et al. Nat. Neurosci. 16, 562–570 (2013).

    Article  CAS  Google Scholar 

  2. Yamamoto, A., Lucas, J.J. & Hen, R. Cell 101, 57–66 (2000).

    Article  CAS  Google Scholar 

  3. Kordasiewicz, H.B. et al. Neuron 74, 1031–1044 (2012).

    Article  CAS  Google Scholar 

  4. Weiss, A. et al. Anal. Biochem. 395, 8–15 (2009).

    Article  CAS  Google Scholar 

  5. Mitra, S., Tsvetkov, A.S. & Finkbeiner, S. Autophagy 5, 1037–1038 (2009).

    Article  CAS  Google Scholar 

  6. Dragatsis, I., Levine, M.S.M. & Zeitlin, S.S. Nat. Genet. 26, 300–306 (2000).

    Article  CAS  Google Scholar 

  7. Kaltenbach, L.S. et al. PLoS Genet. 3, e82 (2007).

    Article  Google Scholar 

  8. Liu, G. & Xirodimas, D.P. Oncogene 29, 2252–2261 (2010).

    Article  CAS  Google Scholar 

  9. Bae, B.-I. et al. Neuron 47, 29–41 (2005).

    Article  CAS  Google Scholar 

  10. Kito, K. J. Biol. Chem. 276, 20603–20609 (2001).

    Article  CAS  Google Scholar 

  11. Bouchard, J. et al. J. Neurosci. 32, 18259–18268 (2012).

    Article  CAS  Google Scholar 

  12. Seifert, U. et al. Cell 142, 613–624 (2010).

    Article  CAS  Google Scholar 

  13. Díaz-Hernández, M. et al. J. Neurosci. 23, 11653–11661 (2003).

    Article  Google Scholar 

  14. Richet, E. et al. Hum. Mol. Genet. 21, 5254–5267 (2012).

    Article  CAS  Google Scholar 

  15. Tanji, K. et al. Am. J. Pathol. 169, 553–565 (2006).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Rebecca Aron, Andrey Tsvetkov and Steven Finkbeiner are at the Gladstone Institutes and Taube-Koret Center for Neurodegenerative Disease, San Francisco, California, USA.,

    Rebecca Aron, Andrey Tsvetkov & Steven Finkbeiner

  2. Steven Finkbeiner is also in the Departments of Neurology and Physiology at the University of California, San Francisco, California, USA.,

    Steven Finkbeiner

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  1. Rebecca Aron
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  2. Andrey Tsvetkov
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  3. Steven Finkbeiner
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Correspondence to Steven Finkbeiner.

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The authors declare no competing financial interests.

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Aron, R., Tsvetkov, A. & Finkbeiner, S. NUB1 snubs huntingtin toxicity. Nat Neurosci 16, 523–525 (2013). https://doi.org/10.1038/nn.3380

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