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UP states rise from the depths

Nature Neuroscience volume 16, pages 115–117 (2013)Cite this article

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A study optogenetically generating or suppressing activity in excitatory neocortical neurons in vivo finds that layer 5 pyramidal cells initiate and maintain widespread UP states, whereas layer 2/3 cells are subsidiary.

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Figure 1: Optogenetic experiments demonstrate that layer 5 pyramidal cells generate and maintain neocortical UP states.

Katie Vicari

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Authors and Affiliations

  1. Stuart Hughes is at Lilly Research Laboratories, Windleshamr, Surrey, UK,

    Stuart Hughes

  2. Vincenzo Crunelli is in the Neuroscience Division, School of Biosciences, Cardiff University, Cardiff, UK.,

    Vincenzo Crunelli

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  1. Stuart Hughes
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  2. Vincenzo Crunelli
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Correspondence to Stuart Hughes or Vincenzo Crunelli.

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The authors declare no competing financial interests.

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Hughes, S., Crunelli, V. UP states rise from the depths. Nat Neurosci 16, 115–117 (2013). https://doi.org/10.1038/nn.3313

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