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Forgiving the sins of the fathers

In a case of sex-linked epigenetic inheritance, paternal cocaine use results in a heritable increase in cortical Bdnf gene expression that confers a cocaine-resistant phenotype in male, but not female, progeny.

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Figure 1: The effect of cocaine history on the acetylation of Bdnf promoter histone proteins in F0 and F1 males.

Katie Vicari

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Correspondence to Michael D Scofield.

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Scofield, M., Kalivas, P. Forgiving the sins of the fathers. Nat Neurosci 16, 4–5 (2013). https://doi.org/10.1038/nn.3288

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