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Breathless without Hox

Sustained activity of Hox5 transcription factors is needed for the development and maintenance of motor neurons that innervate the diaphragm, reports a study in Nature Neuroscience.

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Figure 1: Hox5 and phrenic motor neuron fate specification and maturation.

Marina Corral

References

  1. Philippidou, P., Walsh, C., Aubin, J., Jeannotte, L. & Dasen, J.S. Nat. Neurosci. 15, 1636–1644 (2012).

    Article  CAS  Google Scholar 

  2. Narita, Y. & Rijli, F.M. Curr. Top. Dev. Biol. 88, 139–167 (2009).

    Article  CAS  Google Scholar 

  3. Weiner, J.A. et al. Mol. Cell. Neurosci. 27, 59–69 (2004).

    Article  CAS  Google Scholar 

  4. McGee, A.W., Yang, Y., Fischer, Q.S., Daw, N.W. & Strittmatter, S.M. Science 309, 2222–2226 (2005).

    Article  CAS  Google Scholar 

  5. Jaworski, A. & Tessier-Lavigne, M. Nat. Neurosci. 15, 367–369 (2012).

    Article  CAS  Google Scholar 

  6. Rousso, D.L., Gaber, Z.B., Wellik, D., Morrisey, E.E. & Novitch, B.G. Neuron 59, 226–240 (2008).

    Article  CAS  Google Scholar 

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Correspondence to Valérie Castellani or Artur Kania.

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The authors declare no competing financial interests.

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Castellani, V., Kania, A. Breathless without Hox. Nat Neurosci 15, 1607–1609 (2012). https://doi.org/10.1038/nn.3272

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