Genome-wide approaches are used to discover the RNA-binding targets of the amyotrophic lateral sclerosis (ALS) disease protein FUS/TLS. These studies reveal some shared targets with another ALS-linked RNA-binding protein, TDP-43, suggesting common pathogenic mechanisms.
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Gitler, A. TDP-43 and FUS/TLS yield a target-rich haul in ALS. Nat Neurosci 15, 1467–1469 (2012). https://doi.org/10.1038/nn.3243
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DOI: https://doi.org/10.1038/nn.3243
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