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L-type voltage-dependent Ca2+ channels mediate expression of presynaptic LTP in amygdala

Nature Neuroscience volume 12, pages 1093–1095 (2009)Cite this article

Abstract

The molecular mechanisms underlying the expression of postsynaptic long-term potentiation (LTP) at glutamatergic synapses are well understood. However, little is known about those that mediate the expression of presynaptic LTP. We found that presynaptic LTP at cortical inputs to the mouse lateral amygdala was blocked and reversed by L-type voltage-dependent Ca2+ channel (L-VDCC) blockers. Thus, a persistent increase in L-VDCC–mediated glutamate release underlies the expression of presynaptic LTP in the amygdala.

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Figure 1: Differential role of distinct VDCC subtypes in synaptic transmission and plasticity.
Figure 2: L-VDCC mediate expression of presynaptic LTP.

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Acknowledgements

We thank J. Letzkus and all members of the Lüthi laboratory for helpful discussions and comments on the manuscript. This study was supported by the Agence Nationale pour la Recherche, the European Neuroscience Institutes Network, the Eucor Learning and Teaching Mobility Program, the Swiss National Science Foundation, the Austrian Science Fund and the Novartis Research Foundation.

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Author notes

  1. Elodie Fourcaudot and Frederic Gambino: These authors contributed equally to this work.

Authors and Affiliations

  1. Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland

    Elodie Fourcaudot, Guillaume Casassus, Yann Humeau & Andreas Lüthi

  2. Centre National de la Recherche Scientifique, Strasbourg, UPR3212, France

    Elodie Fourcaudot, Frederic Gambino, Bernard Poulain & Yann Humeau

Authors
  1. Elodie Fourcaudot
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  2. Frederic Gambino
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  3. Guillaume Casassus
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  4. Bernard Poulain
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  5. Yann Humeau
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  6. Andreas Lüthi
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Contributions

E.F., F.G, G.C., B.P., Y.H. and A.L. designed the study. E.F., F.G., G.C. and Y.H. carried out the experiments. E.F., F.G., G.C., B.P., Y.H. and A.L. analyzed the data. E.F., G.C., B.P., Y.H. and A.L. wrote the manuscript.

Corresponding author

Correspondence to Andreas Lüthi.

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Fourcaudot, E., Gambino, F., Casassus, G. et al. L-type voltage-dependent Ca2+ channels mediate expression of presynaptic LTP in amygdala. Nat Neurosci 12, 1093–1095 (2009). https://doi.org/10.1038/nn.2378

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