Abstract
The specific functions of dopamine D2 receptor–positive (D2R) striatopallidal neurons remain poorly understood. Using a genetic mouse model, we found that ablation of D2R neurons in the entire striatum induced hyperlocomotion, whereas ablation in the ventral striatum increased amphetamine conditioned place preference. Thus D2R striatopallidal neurons limit both locomotion and, unexpectedly, drug reinforcement.
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Acknowledgements
We thank M. Picciotto for helpful and critical comments on the manuscript and D. Houtteman, S. Laghmiri and L. Cuvelier for expert technical assistance. P.F.D. is Research Fellow of the Fonds de la Recherche Scientifique (bourse de doctorat Fonds de la Recherche Scientifique) and A.d.K.d.E. is a Research Associate of the Fonds de la Recherche Scientifique (Belgium). This study was supported by Fondation Médicale Reine Elisabeth (Belgium), Fonds de la Recherche Scientifique (Belgium), Fonds d'Encouragement à la Recherche from the Université Libre de Bruxelles, Action de Recherche Concertée from the Communauté Française Wallonie Bruxelles and Ministero Italiano dell'Università e della Ricerca (grant number PRIN20072BTSR2) to M.Z.
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P.F.D., S.N.S. and A.d.K.d.E. conceived and designed the experiments. P.F.D., A.d.K.d.E., B.B. and S.G. carried out the experiments. T.B. and A.W. contributed materials. P.F.D., M.Z., S.N.S. and A.d.K.d.E. analyzed the data and wrote the paper.
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Supplementary Figures 1–7 and Supplementary Methods (PDF 9494 kb)
Supplementary Video 1
Bilateral D2R–striatopallidal neuron loss in the entire striatum induces hyperlocomotion. (MOV 2831 kb)
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Durieux, P., Bearzatto, B., Guiducci, S. et al. D2R striatopallidal neurons inhibit both locomotor and drug reward processes. Nat Neurosci 12, 393–395 (2009). https://doi.org/10.1038/nn.2286
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DOI: https://doi.org/10.1038/nn.2286
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