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ERK-dependent PSD-95 induction in the gustatory cortex is necessary for taste learning, but not retrieval

Nature Neuroscience volume 11, pages 1149–1151 (2008)Cite this article

Abstract

The processes underlying long-term memory formation in the neocortex are poorly understood. Using taste learning, we found learning-related induction of PSD-95 in the gustatory cortex, which was temporally restricted, coupled to the learning of a novel, but not familiar, taste and controlled by ERK. Using temporally and spatially restricted RNA interference knockdown of PSD-95 in vivo, we found that PSD-95 induction is necessary for learning novel tastes, but not for the recollection of familiar ones.

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Figure 1: Specific and transient induction of PSD-95 in gustatory cortex following taste learning.
Figure 2: Novel, but not familiar, tastes increase ERK-dependent PSD-95 expression in the gustatory cortex.
Figure 3: Reduction of PSD-95 expression in the insular cortex attenuates taste learning, but not retrieval.

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Acknowledgements

We thank G. Hannon (Cold Spring Harbor Laboratory) and P. Osten (Northwestern University, USA) for providing DNA vectors. We are grateful for the generous support of R. Malinow (Cold Spring Harbor Laboratory) and A. Lüthi (Friedrich Miescher Institute), in whose laboratories the lentiviruses were produced and characterized. We wish to thank A. Fine for constructive comments on the manuscript. This research was supported by the Israel Science Ffoundation and a Gene Memory Research Training Network EU grant to K.R.

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Authors and Affiliations

  1. Department of Neurobiology and Ethology, Center for Brain and Behavior, University of Haifa, Haifa, 30905, Israel

    Alina Elkobi, Katya Belelovsky, Liza Barki-Harrington & Kobi Rosenblum

  2. Friedrich Miescher Institute, Maulbeerstrasse 66, Basel, 4057, Switzerland

    Ingrid Ehrlich

Authors
  1. Alina Elkobi
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  2. Ingrid Ehrlich
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  3. Katya Belelovsky
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  4. Liza Barki-Harrington
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  5. Kobi Rosenblum
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Correspondence to Kobi Rosenblum.

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Elkobi, A., Ehrlich, I., Belelovsky, K. et al. ERK-dependent PSD-95 induction in the gustatory cortex is necessary for taste learning, but not retrieval. Nat Neurosci 11, 1149–1151 (2008). https://doi.org/10.1038/nn.2190

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