The role of primary visual cortex (V1) in determining the contents of perception is controversial. Human functional magnetic resonance imaging (fMRI) studies of perceptual suppression have revealed a robust drop in V1 activity when a stimulus is subjectively invisible. In contrast, monkey single-unit recordings have failed to demonstrate such perception-locked changes in V1. To investigate the basis of this discrepancy, we measured both the blood oxygen level–dependent (BOLD) response and several electrophysiological signals in two behaving monkeys. We found that all signals were in good agreement during conventional stimulus presentation, showing strong visual modulation to presentation and removal of a stimulus. During perceptual suppression, however, only the BOLD response and the low-frequency local field potential (LFP) power showed decreases, whereas the spiking and high-frequency LFP power were unaffected. These results demonstrate that the coupling between the BOLD and electrophysiological signals in V1 is context dependent, with a marked dissociation occurring during perceptual suppression.
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We would like to thank G. Dold, D. Ide, N. Nichols and T. Talbot, as well as K. Smith, N. Phipps and J. Yu for technical assistance. We also thank H. Merkle for extensive guidance on the design and fabrication of radio frequency coils, R. Cox for assistance with magnetic resonance image alignment, D. Sheinberg for help with the stimulus software, K. King and C. Brewer for auditory testing and ear plug manufacture, W. Vinje for help with the multi-contact electrodes, K. Tanji, A.H. Bell and Z. Saad for help with the fMRI analysis, and S. Guderian, M. Schmid and K.-M. Mueller for discussions. This work was supported by the Intramural Research Programs of the National Institute of Mental Health, the National Institute of Neurological Disorders and Stroke and the National Eye Institute.
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Maier, A., Wilke, M., Aura, C. et al. Divergence of fMRI and neural signals in V1 during perceptual suppression in the awake monkey. Nat Neurosci 11, 1193–1200 (2008) doi:10.1038/nn.2173
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