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Viral pathogenesis: Dengue virus takes on cGAS

Nature Microbiology volume 2, Article number: 17050 (2017) Cite this article

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The sensor cyclic GMP–AMP synthase (cGAS) is well known to recognize viral DNA. In this issue of Nature Microbiology, infection by dengue virus (DENV), which has an RNA genome, is shown to induce mitochondrial DNA release into the cytosol, leading to cGAS activation. In turn, DENV targets cGAS to evade antiviral immunity.

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Figure 1: Dengue virus elicits and blocks cGAS-mediated immunity.

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Authors and Affiliations

  1. Michiel van Gent and Michaela U. Gack are in the Department of Microbiology, University of Chicago, Chicago, Illinois 60637, USA.,

    Michiel van Gent & Michaela U. Gack

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  1. Michiel van Gent
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  2. Michaela U. Gack
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Correspondence to Michaela U. Gack.

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The authors declare no competing financial interests.

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van Gent, M., Gack, M. Viral pathogenesis: Dengue virus takes on cGAS. Nat Microbiol 2, 17050 (2017). https://doi.org/10.1038/nmicrobiol.2017.50

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