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Dengue virus is an infectious agent that causes the tropical disease dengue fever in humans. This virus species is transmitted by mosquitoes (arthropods) and thus is an arbovirus.
In an analysis of severe dengue cases in a cohort of children in India, more than half could be attributed to primary rather than secondary infection, suggesting that primary dengue infections might also contribute substantially to severe disease burden.
There is still a need to improve understanding of dengue-specific immunity. Here, by analyzing the antibody response in a pediatric cohort the authors show that the protective capacity of neutralizing antibodies depends on infection history and serotype, but its estimation varies by assay condition and virion maturation.
Here, Huang et al. show that nuclear membrane proteins SUN2 and Nesprins are required for the in vitro and in vivo replication of Zika virus, through directing the cytoskeleton remodeling and formation of replication organelles mediated by viral NS1.
Antiviral approaches against entire genera or families of viruses need to be constantly developed and innovated. Focusing on several distantly-related orthoflaviviruses, the authors develop a cell-based multiplex antiviral assay for high-throughput screening against multiple viruses at once.
An experimental study on the yellow fever mosquito reveals that inadequate nutrition during both the larval and adult stages could mediate their vectorial capacity by compromising key life history traits and antiviral immune response, while boosting vulnerability to dengue infection.
Anantharaj et al. evaluate the presence of antibodies to dengue in febrile patients and estimate seroprevalence to dengue across the National Capital Region and across different age groups in India. Majority of the adult population have neutralizing antibodies to all four dengue serotypes which correlate with reduced dengue viremia during subsequent infection.
This study suggests that pre-existing DENV immunity has a negative effect on the pathogenesis of secondary ZIKV infection during pregnancy in marmosets.
A new study shows that many olfactory sensory neurons in Aedes aegypti mosquitoes express more than one type of chemosensory receptor and some of these neurons can respond to multiple olfactory cues.