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Pathogenesis: Infections causing gastric cancer

A viral infection can reduce expression of a host phosphatase that would otherwise dampen the oncogenic activity of a bacterial virulence factor. The results suggest a possible mechanism for cooperation of infections in the development of stomach cancer.

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Figure 1: Model for EBV exacerbation of CagA-mediated oncogenic signalling.

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Correspondence to Paul Farrell.

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Farrell, P. Pathogenesis: Infections causing gastric cancer. Nat Microbiol 1, 16038 (2016). https://doi.org/10.1038/nmicrobiol.2016.38

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  • DOI: https://doi.org/10.1038/nmicrobiol.2016.38

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