Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Plasma membrane topography and interpretation of single-particle tracks

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Cell topography compromises interpretation of SPT data.


  1. van Deurs, B., Roepstorff, K., Hommelgaard, A.M. & Sandvig, K. Trends Cell. Biol. 13, 92–100 (2003).

    CAS  Article  Google Scholar 

  2. Andrews, N.L. et al. Nat. Cell Biol. 10, 955–963 (2008).

    CAS  Article  Google Scholar 

  3. Novak, P. et al. Nat. Methods 6, 279–281 (2009).

    CAS  Article  Google Scholar 

  4. Hall, D. Anal. Biochem. 377, 24–32 (2008).

    CAS  Article  Google Scholar 

  5. Werner, J.H. et al. Langmuir 25, 2986–2993 (2009).

    CAS  Article  Google Scholar 

  6. Fujiwara, T., Ritchie, K., Murakoshi, H., Jacobson, K. & Kusumi, A. J. Cell Biol. 157, 1071–1081 (2002).

    CAS  Article  Google Scholar 

  7. Kusumi, A. et al. Annu. Rev. Biophys. Biomol. Struct. 34, 351–378 (2005).

    CAS  Article  Google Scholar 

  8. Ram, S., Prabhat, P., Chao, J., Ward, E.S. & Ober, R.J. Biophys. J. 95, 6025–6043 (2008).

    CAS  Article  Google Scholar 

Download references


This study was supported by Carl Trygger's Fund to J.A. and I.P., the Längmanska's Fund to I.P. and the UK Biotechnology and Biological Sciences Research Council to A.I.S, P.N. and Y.E.K. (BB/D020875).

Author information

Authors and Affiliations


Corresponding author

Correspondence to Ingela Parmryd.

Ethics declarations

Competing interests

P.N. has a consultancy agreement with Ionscope Ltd., a start-up company selling scanning ion conductance microscopes. A.I.S. and Y.E.K. are shareholders of Ionscope Ltd.

Supplementary information

Supplementary Text and Figures

Supplementary Figures 1–6, Supplementary Table 1, Supplementary Note (PDF 1986 kb)

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Adler, J., Shevchuk, A., Novak, P. et al. Plasma membrane topography and interpretation of single-particle tracks. Nat Methods 7, 170–171 (2010).

Download citation

  • Issue Date:

  • DOI:

Further reading


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing