Molecular biology

Watching translation of single mRNAs in cells

Four studies describe methods to image the dynamics of translation at the single-transcript level in real time in living cells, with exciting results.

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References

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    Yan, X. et al. Dynamics of translation of single mRNA molecules in vivo. Cell 165, 976–989 (2016).

  2. 2

    Wang, C. et al. Real-time imaging of translation on single mRNA transcripts in live cells. Cell 165, 990–1001 (2016).

  3. 3

    Wu, B. et al. Translation dynamics of single mRNAs in live cells and neurons. Science http://dx.doi.org/10.1126/science.aaf1084 (2016).

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    Morisaki, T. et al. Real-time quantification of single RNA translation dynamics in living cells. Science http://dx.doi.org/10.1126/science.aaf0899 (2016).

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Strack, R. Watching translation of single mRNAs in cells. Nat Methods 13, 543 (2016) doi:10.1038/nmeth.3914

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