The ORFeome Collaboration: a genome-scale human ORF-clone resource

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Figure 1: RefSeq and Ensembl genes and functional gene categories represented in the OC.


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The authors acknowledge valuable encouragement for initiating the OC from F. Collins (US National Institutes of Health) and E. Harlow (Harvard Medical School). Some of the cDNAs used as PCR templates for ORF cloning and other support were received from the German cDNA Consortium: K. Köhrer (University Düsseldorf, Germany), W. Ansorge (EMBL Heidelberg, Germany), H. Blöcker (Helmholtz Center Braunschweig, Germany), W. Mewes, C. Amid (Helmholtz Center Munich, Germany), J. Lauber, A. Bahr (Qiagen, Hilden, Germany), D. Heubner, R. Wambutt (Agowa, Berlin, Germany), B. Ottenwälder, B. Obermaier (Medigenomix, Ebersberg, Germany), H. Blum, H. Domdey (University Munich, Germany), I. Schupp, S. Bechtel and A. Poustka (DKFZ, Heidelberg, Germany). The German cDNA Consortium was funded by the Federal Ministry of Education and Research (BMBF) in the frame of the German Genome Project (DHGP) and the German National Genome Research Network (NGFN) programs (to S.W.). This work was supported by the Ellison Foundation (grant to M.V. and D.E.H.); the DFCI Institute (Sponsored Research funds to M.V. and D.E.H.); the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan (research grants to Y.H. at the RIKEN Omics Science Center and to P.C. at the RIKEN Center for Life Science Technologies); and the MEXT Genome Network Project (grant to Y.H.).

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Correspondence to Stefan Wiemann or Matthias Harbers or Marc Vidal or Joshua LaBaer or Gary Temple or David E Hill.

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Competing interests

Various coauthors work in companies that license, manufacture and sell research reagents including the ORF clones derived from human genes that are described in this manuscript. The following authors are commercial distributors of OC clones and thus declare competing financial interests: M.H., A.A., M.B., S.H., C.K., B.K., A.L., S.L., J.M., T.M., B.S., A.v.B.S., T.W. and S.Y.

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Supplementary Text

Supplementary Note (PDF 776 kb)

Supplementary Data

Background and structure of OC; description of OC clone collection; evaluation of gene coverage in functional categories; how to obtain OC clones; the OC clone annotation process. (PDF 6194 kb)

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Wiemann, S., Pennacchio, C., Hu, Y. et al. The ORFeome Collaboration: a genome-scale human ORF-clone resource. Nat Methods 13, 191–192 (2016).

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