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Vaccine adjuvants

Softness makes it better

An effective adjuvant for the induction of humoural and cellular immunity is achieved by a Pickering emulsion formulation that allows pliability and mobility of loaded antigens.

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Figure 1: Increased cell delivery of antigen by the Pickering emulsion adjuvant system.

References

  1. Plotkin, S. Proc. Natl Acad. Sci. USA 111, 12283–12287 (2014).

    CAS  Article  Google Scholar 

  2. McKee, A. S. & Marrack, P. Curr. Opin. Immunol. 47, 44–51 (2017).

    CAS  Article  Google Scholar 

  3. Xia, Y. et al. Nat. Mater. 17, 187–194 (2018).

    CAS  Article  Google Scholar 

  4. Didierlaurent, A. M. et al. J. Immunol. 183, 6186–6197 (2009).

    CAS  Article  Google Scholar 

  5. FDA approves new vaccine for prevention of cervical cancer. FDA http://go.nature.com/2EQnm4J (2009).

  6. Vaccari, M. et al. Nat. Med. 22, 762–770 (2016).

    CAS  Article  Google Scholar 

  7. NIAID NIAID Strategic Plan for Research on Vaccine Adjuvants (NIAID, 2010); http://go.nature.com/2CofAO3

  8. Yang, Y. et al. Front. Pharmacol. 8, 287 (2017).

    Article  Google Scholar 

  9. Graham, B. S. et al. PLoS One 5, e11995 (2010).

    Article  Google Scholar 

  10. Nurmatov, U. et al. Allergy 72, 1133–1147 (2017).

    CAS  Article  Google Scholar 

  11. Dowling, D. J. & Levy, O. Pediatr. Infect. Dis. J. 34, 1395–1398 (2015).

    Article  Google Scholar 

Download references

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Correspondence to Herman F. Staats.

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Competing interests

D.J.B. is co-founder and chief operating officer of a company identifying and developing immunomodulators.

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Staats, H., Burkhart, D. Softness makes it better. Nat. Mater. 17, 113–114 (2018). https://doi.org/10.1038/nmat5072

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