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T-cell-mediated cytotoxicity toward platelets in chronic idiopathic thrombocytopenic purpura

Nature Medicine volume 9, pages 1123–1124 (2003)Cite this article

Abstract

Chronic idiopathic thrombocytopenic purpura (ITP) is a bleeding disorder that is characterized by increased platelet destruction and is believed to be autoantibody mediated. In this study, CD3+ T cells from ITP patients had increased expression of genes involved in cell-mediated cytotoxicity. In addition, cytotoxic cell-mediated lysis of autologous platelets was shown in active ITP. Our data suggest that T-cell-mediated cytotoxicity is an alternative mechanism for platelet destruction in ITP.

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Figure 1: Gene expression and fluorescence-activated cell sorting analysis of T cells from ITP patients.
Figure 2: Cell-mediated cytotoxicity against platelets in patients with active chronic ITP.

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Acknowledgements

Grants were from the Swedish Medical Research Council (projects no. 11630, 11285 and 13141) and the IngaBritt and Arne Lundberg Forskningsstiftelse.

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Author notes

  1. Bob Olsson and Per-Ola Andersson: These authors contributed equally to this work.

Authors and Affiliations

  1. Research Center for Endocrinology and Metabolism, Sahlgrenska University Hospital, Göteborg University, Göteborg, SE-413 45, Sweden

    Bob Olsson, Margareta Jernås, Björn Carlsson & Lena M S Carlsson

  2. Department of Internal Medicine, Section of Hematology and Coagulation, Sahlgrenska University Hospital, Göteborg University, Göteborg, SE-413 45, Sweden

    Per-Ola Andersson & Hans Wadenvik

  3. Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, Göteborg University, Göteborg, SE-413 45, Sweden

    Stefan Jacobsson

Authors
  1. Bob Olsson
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Correspondence to Per-Ola Andersson.

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Olsson, B., Andersson, PO., Jernås, M. et al. T-cell-mediated cytotoxicity toward platelets in chronic idiopathic thrombocytopenic purpura. Nat Med 9, 1123–1124 (2003). https://doi.org/10.1038/nm921

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