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AIDS restriction HLA allotypes target distinct intervals of HIV-1 pathogenesis

Nature Medicine volume 11, pages 1290–1292 (2005)Cite this article

Abstract

An effective acquired immune response to infectious agents mediated by HLA-restricted T-cell recognition can target different stages of disease pathogenesis. We show here that three distinct HLA alleles known to alter the overall rate of AIDS progression act during distinct intervals after HIV-1 infection. The discrete timing of HLA allele influence suggests alternative functional mechanisms in immune defense against this dynamic and chronic immunosuppressive disease.

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Figure 1: Effect of HLA alleles on different stages of AIDS progression.

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Acknowledgements

This study has been funded in part with federal funds from the US National Cancer Institute (NCI), US National Institutes of Health (NIH), under Contract No. NO1-CO-12400, the US National Institute on Drug Abuse (DA 04334), and by the Intramural Research Program of the NIH, NCI, Center for Cancer Research. We wish to thank P. Goulder and C. O'hUigin for helpful discussions. The study was approved by the Protocol Review Office of the NCI institutional review board. Informed consent was obtained at the study sites from all individuals.

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Authors and Affiliations

  1. Laboratory of Genomic Diversity, NCI-Frederick, Basic Research Program, SAIC Frederick, P.O. Box B, Frederick, 21702, Maryland, USA

    Xiaojiang Gao & Mary Carrington

  2. Johns Hopkins University School of Medicine, 1503 East Jefferson Street, Baltimore, 21231, Maryland, USA

    Arman Bashirova

  3. MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, OX3 9DS, Oxford, UK

    Astrid K N Iversen

  4. Howard Brown Health Center and The Fineberg School of Medicine, Northwestern University, 4025 North Sheridan Road, Chicago, 60611, Illinois, USA

    John Phair

  5. Division of Cancer Epidemiology and Genetics, Viral Epidemiology Branch, National Cancer Institute, Bethesda, 20892, Maryland, USA

    James J Goedert

  6. San Francisco Department of Public Health, 101 Grove Street, San Francisco, 94102, California, USA

    Susan Buchbinder

  7. Gulf States Hemophilia Center, University of Texas Health Science Center, 6655 Travis Street #400, Houston, 77030, Texas, USA

    Keith Hoots

  8. Center for Urban Epidemiologic Studies, New York Academy of Medicine, 1216 Fifth Avenue, New York, 10029, New York, USA

    David Vlahov

  9. Partners AIDS Research Center, Massachusetts General Hospital, 55 Fruit Street, Charlestown, 02129, Massachusetts, USA

    Marcus Altfeld

  10. Laboratory of Genomic Diversity, National Cancer Institute, P.O. Box B, Building 560, Frederick, 21702, Maryland, USA

    Stephen J O'Brien

Authors
  1. Xiaojiang Gao
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  2. Arman Bashirova
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  3. Astrid K N Iversen
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  4. John Phair
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  5. James J Goedert
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  6. Susan Buchbinder
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  7. Keith Hoots
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  8. David Vlahov
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  9. Marcus Altfeld
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  10. Stephen J O'Brien
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  11. Mary Carrington
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Corresponding author

Correspondence to Mary Carrington.

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Competing interests

The authors declare no competing financial interests.

Supplementary information

Supplementary Table 1

Effect of HLA class I alleles on AIDS progression in 1,089 seroconverters. (PDF 17 kb)

Supplementary Methods (PDF 81 kb)

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Gao, X., Bashirova, A., Iversen, A. et al. AIDS restriction HLA allotypes target distinct intervals of HIV-1 pathogenesis. Nat Med 11, 1290–1292 (2005). https://doi.org/10.1038/nm1333

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