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Protection of macaques from vaginal SHIV challenge by an orally delivered CCR5 inhibitor


Pre-exposure oral prophylaxis with antiviral drugs is a potential method for preventing transmission of human immunodeficiency virus type 1 (HIV-1). We show that oral delivery of CMPD167, a small molecule that binds to the CCR5 coreceptor, for 10–14 d can protect a substantial proportion of macaques from vaginal infection with a CCR5-using virus (SHIV-162P3). The macaques that became infected despite receiving CMPD167 had reduced plasma viremia levels during the earliest stages of infection.

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Figure 1: Plasma viral load in SHIV-162P3-infected animals.


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Correspondence to John P Moore.

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Martin S. Springer is an employee of Merck Inc., but this company did not fund the study.

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Veazey, R., Springer, M., Marx, P. et al. Protection of macaques from vaginal SHIV challenge by an orally delivered CCR5 inhibitor. Nat Med 11, 1293–1294 (2005).

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