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Protection of macaques from vaginal SHIV challenge by an orally delivered CCR5 inhibitor

Nature Medicine volume 11, pages 1293–1294 (2005)Cite this article

Abstract

Pre-exposure oral prophylaxis with antiviral drugs is a potential method for preventing transmission of human immunodeficiency virus type 1 (HIV-1). We show that oral delivery of CMPD167, a small molecule that binds to the CCR5 coreceptor, for 10–14 d can protect a substantial proportion of macaques from vaginal infection with a CCR5-using virus (SHIV-162P3). The macaques that became infected despite receiving CMPD167 had reduced plasma viremia levels during the earliest stages of infection.

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Figure 1: Plasma viral load in SHIV-162P3-infected animals.

References

  1. Youle, M. & Wainberg, M.A. AIDS 17, 937–938 (2003).

    Article  Google Scholar 

  2. Shattock, R.J. & Moore, J.P. Nat. Rev. Microbiol. 1, 25–34 (2003).

    Article  CAS  Google Scholar 

  3. AIDS Vaccine Advocacy Coalition. Will a pill a day prevent HIV? Anticipating the results of the tenofovir “PREP” trials. A special publication of the AIDS Vaccine Advocacy Coalition (AVAC). http://www.avac.org/pdf/tenofovir.pdf. (2005).

  4. Seibert, C. & Sakmar, T.P. Curr. Pharm. Des. 10, 2041–2062 (2004).

    Article  CAS  Google Scholar 

  5. Barber, C.G. Curr. Opin. Investig. Drugs 5, 851–861 (2004).

    CAS  PubMed  Google Scholar 

  6. Watson, C., Jenkinson, S., Kazmierski, W. & Kenakin, T.P. Mol. Pharmacol. 67, 1268–1282 (2005).

    Article  CAS  Google Scholar 

  7. Kuhmann, S.E. et al. J. Virol. 78, 2790–2807 (2004).

    Article  CAS  Google Scholar 

  8. Veazey, R.S. & Lackner, A.A. Nat. Med. 11, 469–470 (2005).

    Article  CAS  Google Scholar 

  9. Veazey, R.S. et al. Nature, published online 30 October 2005 (10.1038/nature04055).

  10. Veazey, R.S. et al. J. Exp. Med. 198, 1551–1562 (2003).

    Article  CAS  Google Scholar 

  11. Wolinsky, S.M. et al. Virology 328, 19–29 (2004).

    Article  CAS  Google Scholar 

  12. Tsai, C.C. et al. Science 270, 1197–1199 (1995).

    Article  CAS  Google Scholar 

  13. Tsai, C.C. et al. J. Virol. 72, 4265–4273 (1998).

    CAS  PubMed  PubMed Central  Google Scholar 

  14. Marx, P.A. et al. Nat. Med. 2, 1084–1089 (1996).

    Article  CAS  Google Scholar 

Download references

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Author notes

  1. Ronald S Veazey and Martin S Springer: These authors contributed equally to this work.

Authors and Affiliations

  1. Tulane National Primate Research Center, 18703 Three Rivers Road, Covington, 70433, Louisiana, USA

    Ronald S Veazey, Preston A Marx & Jason Dufour

  2. Merck Research Laboratories, 126 East Lincoln Avenue, Rahway, 07065, New Jersey, USA

    Martin S Springer

  3. Department of Microbiology and Immunology, Weill Medical College of Cornell University, 1300 York Avenue, W-805, New York, 10021, New York, USA

    Per Johan Klasse & John P Moore

Authors
  1. Ronald S Veazey
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  2. Martin S Springer
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  3. Preston A Marx
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  4. Jason Dufour
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  5. Per Johan Klasse
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  6. John P Moore
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Corresponding author

Correspondence to John P Moore.

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Competing interests

Martin S. Springer is an employee of Merck Inc., but this company did not fund the study.

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Veazey, R., Springer, M., Marx, P. et al. Protection of macaques from vaginal SHIV challenge by an orally delivered CCR5 inhibitor. Nat Med 11, 1293–1294 (2005). https://doi.org/10.1038/nm1321

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