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Runt domains take the lead in hematopoiesis and osteogenesis


It has been nearly a decade since AML1 was first identified as the DNA-binding protein PEBP2αB/CBFA2 in mice. Molecular, genetic and biochemical studies have converged to reveal new information about how this unique family of transcription factors functions, and the linkage between developmental processes and human disease.

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Figure 1: Three-dimensional structure of the Runt domain and location of mutations causing deficiencies in DNA binding associated with AML, FPD and CCD.


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Werner, M., Shigesada, K. & Ito, Y. Runt domains take the lead in hematopoiesis and osteogenesis. Nat Med 5, 1356–1357 (1999).

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