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Aspirin for cancer

Nature Medicine volume 5, pages 1348–1349 (1999)Cite this article

Abstract

Cyclooxygenase inhibitors are well known for their anti-inflammatory effects, but recent data indicate that they are also potent anti-angiogenics. The mechanisms by which nonsteroidal anti-inflammatory drugs affect cyclooxygenase enzymes, peptic ulcers, angiogenesis and cancer are complex, but are worth sorting out (pages 1418–1423).

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Figure 1: Angiogenesis is essential for tumor development, and probably also for peptic ulcer healing.

References

  1. Jones, M.K. et al. Inhibition of angiogenesis by NSAIDs: insight into the mechanisms and implications for cancer growth and ulcer healing. Nature Med. 5, 1418–1423 ( 1999).

    Article  CAS  Google Scholar 

  2. Shiff, S.J. & Rigas, B. Nonsteroidal anti-inflammatory drugs and colorectal cancer: Evolving concepts of their chemopreventive actions. Gastroenterology 113, 1992– 1998 (1997).

    Article  CAS  Google Scholar 

  3. Shiff, S.J. & Rigas, B. The role of cyclooxygenase inhibition in the antineoplastic effects of nonsteroidal antiinflammatory drugs (NSAIDs). J. Exp. Med. 190, 445– 450 (1999).

    Article  CAS  Google Scholar 

  4. Peterson, H.I. Effects of prostaglandin synthesis inhibitors on tumor growth and vascularization. Experimental studies in the rat. Invasion Metastasis 3, 151–159 (1983).

    CAS  PubMed  Google Scholar 

  5. Tsujii, M. et al. Cyclooxygenase regulates angiogenesis induced by colon cancer cells. Cell 93, 705–716 (1998).

    Article  CAS  Google Scholar 

  6. Skopinska-Rózewska, E. et al. Inhibition of angiogenesis by sulindac and its sulfone metabolite (FGN-1): A potential mechanism for their antineoplastic properties. Int. J. of Tissue React. 20, 85–89 (1998).

    Google Scholar 

  7. Mitchell, J.A., Akarasereenont, P., Thiemermann, C., Flower, R.J. & Vane, J.R. Selectivity of nonsteroidal anti-inflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc. of the Natl. Acad. Sci. USA 90, 11693– 11697 (1993).

    Article  CAS  Google Scholar 

  8. Meade, E.A., Smith, W.L. & DeWitt, D.L. Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal antiinflammatory drugs. J. Biol. Chem. 268, 6610– 6614 (1993).

    CAS  PubMed  Google Scholar 

  9. Schmassmann, A. et al. Effects of inhibition of prostaglandin endoperoxide synthase-2 in chronic gastro-intestinal ulcer models in rats. Br. J. Pharmacol. 123, 795–804 (1998).

    Article  CAS  Google Scholar 

  10. Mizuno, H. et al. Induction of cyclooxygenase 2 in gastric mucosal lesions and its inhibition by the specific antagonist delays healing in mice. Gastroenterology 112, 387–397 (1997).

    Article  CAS  Google Scholar 

  11. Fenn, G.C. Controversies in NSAID-induced gastroduodenal damage—do they matter? Aliment. Pharmacol. Ther. 8, 15– 26 (1994).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. The Rockefeller University, 1230 York Avenue, New York, 10021, New York, USA

    Steven J. Shiff & Basil Rigas

  2. The American Health Foundation, 1 Dana Road, Valhalla, 10595, New York, USA

    Basil Rigas

  3. New York Medical College, 1 Dana Road , Valhalla, 10595, New York, USA

    Basil Rigas

Authors
  1. Steven J. Shiff
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  2. Basil Rigas
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Shiff, S., Rigas, B. Aspirin for cancer. Nat Med 5, 1348–1349 (1999). https://doi.org/10.1038/70909

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