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Thymosin β15: A novel regulator of tumor cell motility upregulated in metastatic prostate cancer

Nature Medicine volume 2, pages 1322–1328 (1996)Cite this article

Abstract

The Dunning rat prostatic carcinoma is a model system where cell motility closely correlates with the metastatic phenotype. We have identified a novel gene, upregulated in the highly motile and metastatic Dunning cancer cell lines, that represents a new member of the thymosin–beta family, thymosin β15. Transfection of antisense thymosin β15 constructs into rat prostatic carcinoma cells demonstrates that this molecule positively regulates cell motility, a critical component of the metastatic pathway. Thymosin β15 levels are elevated in human prostate cancer and correlate positively with the Gleason tumor grade. Thymosin β15 may represent a potential new biochemical marker for human prostate cancer progression.

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Authors and Affiliations

  1. Department of Surgery and Cell Biology, Harvard Medical School, Children's Hospital, Enders 1074, 300 Longwood Avenue, Boston, Massachusetts, 02115, USA

    Lere Bao, Robert Stewart, Bela Anand-Apte & Bruce R. Zetter

  2. Department of Pathology, Harvard Medical School, Deaconess Hospital, One Deaconess Street, Boston, Massachusetts, 02115, USA

    Massimo Loda

  3. Division of Experimental Medicine, Harvard Medical School, Brigham and Women's Hospital, 75 Francis Street, Boston, Massachusetts, 02115, USA

    Paul A. Janmey

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Bao, L., Loda, M., Janmey, P. et al. Thymosin β15: A novel regulator of tumor cell motility upregulated in metastatic prostate cancer. Nat Med 2, 1322–1328 (1996). https://doi.org/10.1038/nm1296-1322

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