Community Corner | Published:

Mixed results for a malaria vaccine

Nature Medicine volume 17, pages 15601561 (2011) | Download Citation

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1.

    The RTS,S Cinical Trials Partnership. first results of phase 3 trial of RTS,S/AS01 malaria vaccine in African children. N. Engl. J. Med. published online, 10.1056/nejmoa1102287 (18 October 2011).

  2. 2.

    , , , & From the circumsporozoite protein to the RTS, S vaccine. Hum. Vaccin. 6, 90–96 (2010).

  3. 3.

    et al. Priming with an adenovirus 35-circumsporozoite protein (CS) vaccine followed by RTS,S/AS01B improves immunogenicity to Plasmodium falciparum CS compared to that with either malaria vaccine alone. Infect. Immun. 75, 2283–2290 (2007).

  4. 4.

    et al. Efficacy of RTS,S/AS02 malaria vaccine against Plasmodium falciparum infection in semi-immune adult men in The Gambia: a randomised trial. Lancet 358, 1927–1934 (2001).

  5. 5.

    Our impasse in developing a malaria vaccine. Cell. Mol. Life Sci. 68, 1105–1113 (2011).

  6. 6.

    , , & et al. Contrasting population structures of the genes encoding ten leading malaria vaccine-candidate antigens of the human malaria parasite, Plasmodium falciparum. PLoS One 4, e8497 (2009).

  7. 7.

    et al. Efficacy of RTS,S/AS01E vaccine against malaria in children 5 to 17 months of age. N. Engl. J. Med. 359, 2521–2532 (2008).

  8. 8.

    et al. Safety and efficacy of the RTS,S/AS01(E) candidate malaria vaccine given with expanded-programme-on-immunisation vaccines: 19 month follow-up of a randomised, open-label, phase 2 trial. Lancet Infect. Dis. 11, 741–749 (2011).

  9. 9.

    , & Measurement of malaria vaccine efficacy in phase III trials: report of a WHO consultation. Vaccine 25, 5115–5123 (2007).

  10. 10.

    et al. Duration of protection with RTS,S/AS02A malaria vaccine in prevention of Plasmodium falciparum disease in Mozambican children: single-blind extended follow-up of a randomised controlled trial. Lancet 366, 2012–2018 (2005).

Download references

About this article

Publication history




    Further reading

    Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing