The chromatin remodeling complex SWI-SNF is altered in cancer. New findings now show that the core component SNF5 can block a Hedgehog (Hh) effector, which promotes malignant rhabdoid tumor growth when SNF5 is lost (pages 1429–1433). Targeting this Hh effector may be a way to combat these aggressive childhood tumors.
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Marina Corral
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Reiter, J. Crippling SWI-SNF makes tumors GLI-ful. Nat Med 16, 1374–1376 (2010). https://doi.org/10.1038/nm1210-1374
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DOI: https://doi.org/10.1038/nm1210-1374
