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Beyond TGF-β: a prostaglandin promotes fibrosis

The deposition of excess scar tissue that occurs in lung fibrosis is known to be mediated by transforming growth factor-β (TGF-β). Prostaglandin F and the F prostanoid (FP) receptor are now identified as mediators that act independently of TGF-β (pages 1426–1430).

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Figure 1: PGF induces pulmonary fibrosis through FP receptor signals.

Kim Caesar

References

  1. Oga, T. et al. Nat. Med. 15, 1426–1430 (2009).

    Article  CAS  Google Scholar 

  2. von Euler, U.S. J. Physiol. (Lond.) 88, 213–234 (1936).

    Article  CAS  Google Scholar 

  3. Vane, J.R. Nat. New Biol. 231, 232–235 (1971).

    Article  CAS  Google Scholar 

  4. Nagase, T. et al. Nat. Med. 8, 480 (2002).

    Article  CAS  Google Scholar 

  5. Keerthisingam, C.B. et al. Am. J. Pathol. 158, 1411–1422 (2001).

    Article  CAS  Google Scholar 

  6. Huang, S.K. et al. Am. J. Respir. Crit. Care Med. 177, 66–74 (2008).

    Article  CAS  Google Scholar 

  7. White, K.E. et al. J. Immunol. 180, 637–646 (2008).

    Article  CAS  Google Scholar 

  8. Munger, J.S. et al. Cell 96, 319–328 (1999).

    Article  CAS  Google Scholar 

  9. Hinz, B. et al. Am. J. Pathol. 170, 1807–1816 (2007).

    Article  CAS  Google Scholar 

  10. Ding, Q. et al. J. Biol. Chem. 283, 26839–26849 (2008).

    Article  CAS  Google Scholar 

  11. Fujino, H. et al. J. Biol. Chem. 277, 48786–48795 (2002).

    Article  CAS  Google Scholar 

  12. Kim, K.K. et al. J. Clin. Invest. 119, 213–224 (2009).

    CAS  PubMed  Google Scholar 

  13. Phan, S.H. et al. Am. Rev. Respir. Dis. 124, 428–434 (1981).

    CAS  PubMed  Google Scholar 

  14. Bean, G.W. et al. Surv. Ophthalmol. 53, S69–S84 (2008).

    Article  Google Scholar 

  15. Olson, D. et al. Front. Biosci. 12, 1329 (2007).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Mitchell A Olman.

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Olman, M. Beyond TGF-β: a prostaglandin promotes fibrosis. Nat Med 15, 1360–1361 (2009). https://doi.org/10.1038/nm1209-1360

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