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Beyond TGF-β: a prostaglandin promotes fibrosis

Nature Medicine volume 15, pages 1360–1361 (2009)Cite this article

The deposition of excess scar tissue that occurs in lung fibrosis is known to be mediated by transforming growth factor-β (TGF-β). Prostaglandin F2α and the F prostanoid (FP) receptor are now identified as mediators that act independently of TGF-β (pages 1426–1430).

How do you see beyond the lion crouched in the bushes poised to strike? In this case, the lion is the growth factor TGF-β. Its reign atop the jungle of factors that mediate fibrosis has been shot down a notch.

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Figure 1: PGF2α induces pulmonary fibrosis through FP receptor signals.

Kim Caesar

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  1. Mitchell A. Olman is in the Department of Pathobiology, Lerner Research Institute and Respiratory Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA.,

    Mitchell A Olman

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  1. Mitchell A Olman
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Correspondence to Mitchell A Olman.

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Olman, M. Beyond TGF-β: a prostaglandin promotes fibrosis. Nat Med 15, 1360–1361 (2009). https://doi.org/10.1038/nm1209-1360

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