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Beyond TGF-β: a prostaglandin promotes fibrosis

The deposition of excess scar tissue that occurs in lung fibrosis is known to be mediated by transforming growth factor-β (TGF-β). Prostaglandin F and the F prostanoid (FP) receptor are now identified as mediators that act independently of TGF-β (pages 1426–1430).

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Figure 1: PGF induces pulmonary fibrosis through FP receptor signals.

Kim Caesar


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Correspondence to Mitchell A Olman.

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Olman, M. Beyond TGF-β: a prostaglandin promotes fibrosis. Nat Med 15, 1360–1361 (2009).

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