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Atherosclerosis: keep your macrophages in shape

Nature Medicine volume 15, pages 13571358 (2009) | Download Citation

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Lipid accumulation leads to atherosclerosis partly by eliciting lethal levels of cellular stress in macrophages. A signaling pathway that drives such lipid-induced toxicity is now identified. The findings reveal a chaperoning function that might provide the clue needed to rescue this pathogenic effect (pages 1383–1391).

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Affiliations

  1. Xueqing Liu and James M. Ntambi are in the Department of Biochemistry, and James M. Ntambi is also in the Department of Nutritional Sciences, University of Wisconsin–Madison, Madison, Wisconsin, USA.

    • Xueqing Liu
    •  & James M Ntambi

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Correspondence to James M Ntambi.

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DOI

https://doi.org/10.1038/nm1209-1357

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