An explanation has come to light for the long-observed phenomenon that ultraviolet light suppresses the immune response in the skin. Light and other stimuli prompt the proliferation of regulatory T cells through the upregulation of receptor activator of NF-κB ligand (RANKL) on skin cells (pages 1372–1379).
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Yamaguchi, T., Sakaguchi, S. Skin controls immune regulators. Nat Med 12, 1358–1359 (2006). https://doi.org/10.1038/nm1206-1358
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DOI: https://doi.org/10.1038/nm1206-1358
