Certain oncogenes seem to be able to trigger cellular senescence and growth arrest, thereby holding cancer at bay. Two new studies suggest that oncogenes trigger senescence through activation of a pathway initially described as sensing DNA damage.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Kim Caesar
References
Di Micco, R. et al. Nature (2006). 444, 638–642.
Bartkova, J. et al. Nature (2006). 444, 633–637.
Serrano, M., Lin, A.W., McCurrach, M.E., Beach, D. & Lowe, S.W. Cell 88, 593–602 (1997).
d'Adda di Fagagna, F. et al. Nature 426, 194–198 (2003).
Bartkova, J. et al. Nature 434, 864–870 (2005).
Gorgoulis, V.G. et al. Nature 434, 907–913 (2005).
Pusapati, R.V. et al. Proc. Natl. Acad. Sci. USA 103, 1446–1451 (2006).
Janzen, V. et al. Nature 443, 421–426 (2006).
Krishnamurthy, J. et al. Nature 443, 453–457 (2006).
Molofsky, A.V. et al. Nature 443, 448–452 (2006).
Cao, L., Li, W., Kim, S., Brodie, S.G. & Deng, C.X. Genes Dev. 17, 201–213 (2003).
Cao, L. et al. EMBO J. 25, 2167–2177 (2006).
Lee, A.C. et al. J. Biol. Chem. 274, 7936–7940 (1999).
Vafa, O. et al. Mol. Cell 9, 1031–1044 (2002).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Cao, L., Finkel, T. Cancer gets the Chk'ered flag. Nat Med 12, 1354–1356 (2006). https://doi.org/10.1038/nm1206-1354
Issue Date:
DOI: https://doi.org/10.1038/nm1206-1354
