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A radically twisted lipid regulates vascular death

Nature Medicine volume 11, pages 1275–1276 (2005)Cite this article

Maintenance of the retinal vasculature protects against proliferative retinopathy and blindness. Lipids and free radicals together modulate vascular stability through regulation of antiangiogenic proteins (pages 1339–1345).

Regulated development of blood vessels in the retina is vital for the preservation of vision. Retinal neovascularization, resulting in bleeding and retinal detachment, is a major cause of blindness in retinopathy of prematurity (ROP), diabetic retinopathy and age-related macular degeneration. Paradoxically, the growth of new blood vessels results from vascular regression, which is the primary pathology; regression leads to hypoxia, which prompts vessel growth.

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Figure 1: Trans-arachidonic acids regulate retinal vascular regression.

Katie Ris

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  1. Children's Hospital, Harvard Medical School, Boston, 02115, Massachusetts, USA

    Lois E H Smith & Kip M Connor

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  1. Lois E H Smith
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  2. Kip M Connor
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Smith, L., Connor, K. A radically twisted lipid regulates vascular death. Nat Med 11, 1275–1276 (2005). https://doi.org/10.1038/nm1205-1275

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