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Cancer drug discovery: the wisdom of imprecision

Drug discovery is either an exact business that is based on detailed knowledge of target structure or it is a fishing expedition that uncovers new drugs through screening of random compounds for their biological effect on target function. Isolation of a new p53 activator with anticancer properties strengthens the reputation of this second approach (pages 1321–1328).

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Figure 1: Disrupting p53–HDM-2 interaction by small molecules: two targeting approaches.

References

  1. Issaeva, N. et al. Nat. Med. 10, 1321–1328 (2004).

    CAS  Article  Google Scholar 

  2. Fischer, P.M. & Lane, D.P. Trends Pharmacol. Sci. 25 343–346 (2004).

    CAS  Article  Google Scholar 

  3. Vassilev, L.T. et al. Science 303, 844–848 (2004).

    CAS  Article  Google Scholar 

  4. Bykov, V.J. et al. Nat. Med. 8, 282–288 (2002).

    CAS  Article  Google Scholar 

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Gudkov, A. Cancer drug discovery: the wisdom of imprecision. Nat Med 10, 1298–1299 (2004). https://doi.org/10.1038/nm1204-1298

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