Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Combination stroke therapy: easy as APC?

The US Food and Drug Administration has approved only one therapy for ischemic stroke, recombinant tissue plasminogen activator (tPA), which can increase blood flow to damaged brain tissue—but it can also have severe side effects and must be administered shortly after stroke. Experiments combining the drug with activated protein C (APC) may provide a solution (pages 1379–1383).

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Two-stroke approach to stroke.

Deborah Maizels


  1. Kaur, J., Zhao, Z., Klein, G.M., Lo, E.H. & Buchan, A.M. J. Cereb. Blood Flow Metab. 24, 945–963 (2004).

    CAS  Article  Google Scholar 

  2. Liu, D. et al. Nat. Med. 10, 1379–1383 (2004).

    CAS  Article  Google Scholar 

  3. Bernard GR, et al. N. Engl. J. Med. 344, 699–709 (2001).

    CAS  Article  Google Scholar 

  4. Wang, Y.F. et al. Nat. Med. 4, 228–231 (1998).

    CAS  Article  Google Scholar 

  5. Nicole, O. et al. Nat. Med. 7, 59–64 (2001).

    CAS  Article  Google Scholar 

  6. Wang, X. et al. Nat. Med. 9, 1313–1317 (2003).

    CAS  Article  Google Scholar 

  7. Lee, S.R. & Lo, E.H. J. Cereb. Blood Flow Metab. 24, 720–727 (2004).

    CAS  Article  Google Scholar 

  8. Yepes, M. et al. J. Clin. Invest. 112, 1533–1540 (2003).

    CAS  Article  Google Scholar 

  9. Cheng, T. et al. Nat. Med. 9, 338–342 (2003).

    CAS  Article  Google Scholar 

  10. Guo, H. et al. Neuron 41, 563–572 (2004).

    CAS  Article  Google Scholar 

  11. Tagaya, M. et al. Stroke 28, 1245–1254 (1997).

    CAS  Article  Google Scholar 

  12. Junge, C.E. et al. Proc. Natl. Acad. Sci. USA 100, 13019–13024 (2003).

    CAS  Article  Google Scholar 

  13. Nguyen, M., Arkell, J. & Jackson, C.J. J. Biol. Chem. 275, 9095–9098 (2000).

    CAS  Article  Google Scholar 

  14. Lo, E.H., Dalkara, T. & Moskowitz, M.A. Nat. Rev. Neurosci. 4, 399–415 (2003)

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and Permissions

About this article

Cite this article

Lo, E. Combination stroke therapy: easy as APC?. Nat Med 10, 1295–1296 (2004).

Download citation

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing