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Combination stroke therapy: easy as APC?

Nature Medicine volume 10, pages 1295–1296 (2004)Cite this article

The US Food and Drug Administration has approved only one therapy for ischemic stroke, recombinant tissue plasminogen activator (tPA), which can increase blood flow to damaged brain tissue—but it can also have severe side effects and must be administered shortly after stroke. Experiments combining the drug with activated protein C (APC) may provide a solution (pages 1379–1383).

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Figure 1: Two-stroke approach to stroke.

Deborah Maizels

References

  1. Kaur, J., Zhao, Z., Klein, G.M., Lo, E.H. & Buchan, A.M. J. Cereb. Blood Flow Metab. 24, 945–963 (2004).

    Article  CAS  Google Scholar 

  2. Liu, D. et al. Nat. Med. 10, 1379–1383 (2004).

    Article  CAS  Google Scholar 

  3. Bernard GR, et al. N. Engl. J. Med. 344, 699–709 (2001).

    Article  CAS  Google Scholar 

  4. Wang, Y.F. et al. Nat. Med. 4, 228–231 (1998).

    Article  CAS  Google Scholar 

  5. Nicole, O. et al. Nat. Med. 7, 59–64 (2001).

    Article  CAS  Google Scholar 

  6. Wang, X. et al. Nat. Med. 9, 1313–1317 (2003).

    Article  CAS  Google Scholar 

  7. Lee, S.R. & Lo, E.H. J. Cereb. Blood Flow Metab. 24, 720–727 (2004).

    Article  CAS  Google Scholar 

  8. Yepes, M. et al. J. Clin. Invest. 112, 1533–1540 (2003).

    Article  CAS  Google Scholar 

  9. Cheng, T. et al. Nat. Med. 9, 338–342 (2003).

    Article  CAS  Google Scholar 

  10. Guo, H. et al. Neuron 41, 563–572 (2004).

    Article  CAS  Google Scholar 

  11. Tagaya, M. et al. Stroke 28, 1245–1254 (1997).

    Article  CAS  Google Scholar 

  12. Junge, C.E. et al. Proc. Natl. Acad. Sci. USA 100, 13019–13024 (2003).

    Article  CAS  Google Scholar 

  13. Nguyen, M., Arkell, J. & Jackson, C.J. J. Biol. Chem. 275, 9095–9098 (2000).

    Article  CAS  Google Scholar 

  14. Lo, E.H., Dalkara, T. & Moskowitz, M.A. Nat. Rev. Neurosci. 4, 399–415 (2003)

    Article  CAS  Google Scholar 

Download references

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  1. Departments of Radiology and Neurology, Neuroprotection Research Laboratory, Massachusetts General Hospital and the Program in Neuroscience, Harvard Medical School, Boston, Massachusetts, USA

    Eng H Lo

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  1. Eng H Lo
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Lo, E. Combination stroke therapy: easy as APC?. Nat Med 10, 1295–1296 (2004). https://doi.org/10.1038/nm1204-1295

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