Infection of tissues outside the nervous system occurs in a number of prion diseases, but sporadic Creutzfeldt-Jakob disease in humans has not been considered one of them. A clinical study of Swiss patients with sporadic disease reconsiders this assumption, and a second study examines the spread of infection between follicular dendritic cells and nerves.
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References
Prinz, M. et al. Nature 425, 957–962 (2003).
Glatzel, M., Abela, E., Maissen, M. & Aguzzi, A. N. Engl. J. Med. 349, 1812–1820 (2003).
Mabbott, N.A., Mackay, F., Minns, F. & Bruce, M.E. Nat. Med. 6, 719–720 (2000).
Montrasio, F. et al. Science 288, 1257–1259 (2000).
Glatzel, M., Heppner, F.L., Albers, K.M. & Aguzzi, A. Neuron 31, 25–34 (2001).
Mackay, F. & Browning, J.L. Nature 395, 26–27 (1998).
Beekes, M. & McBride, P.A. Neurosci. Lett. 278, 181–184 (2000).
Mabbott, N.A., Young, J., McConnell, I. & Bruce, M.E. J. Virol. 77, 6845–6854 (2003).
Yeung, M.M.-W. et al. Gut 47, 215–227 (2000).
Bruce, M.E., McConnell, I., Will, R.G. & Ironside, J.W. Lancet 358, 208–209 (2001).
Hilton, D., Fathers, E., Edwards, P., Ironside, J. & Zajicek, J. Lancet 352, 703–704 (1998).
Wadsworth, J.D.F et al. Lancet 358, 171–180 (2001).
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Mabbott, N., Bruce, M. Prion disease: bridging the spleen-nerve gap. Nat Med 9, 1463–1464 (2003). https://doi.org/10.1038/nm1203-1463
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DOI: https://doi.org/10.1038/nm1203-1463