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Skin antibiotics get in the loop

Nature Medicine volume 8, pages 1359–1360 (2002)Cite this article

Epithelial peptides called defensins can kill microbes directly. New data reveal another function for some of these host antibiotics—enhancement of the innate immune response.

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Figure 1: β-Defensin 2: Carrier or ligand? Immature DCs are induced to mature by interacting with bacterial products such as LPS via engagement of Toll-like receptors on the surface of the DCs.

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Authors and Affiliations

  1. Section of Immunobiology, Yale University, New Haven, Connecticut, USA

    Elizabeth Kopp

  2. Howard Hughes Medical Institute, New Haven, Connecticut, USA

    Ruslan Medzhitov

Authors
  1. Elizabeth Kopp
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  2. Ruslan Medzhitov
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Kopp, E., Medzhitov, R. Skin antibiotics get in the loop. Nat Med 8, 1359–1360 (2002). https://doi.org/10.1038/nm1202-1359

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