Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Seeing death in the living

Nature Medicine volume 7, pages 1277–1278 (2001)Cite this article

Cardiomyocyte apoptosis occurs during reperfusion injury, transplant rejection and heart failure. The ability to image apoptosis non-invasively in the intact heart could lead to a more precise assessment of the clinical condition of patients, and could also expedite therapy. (pages 1347–1352 and 1352–1355)

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Apoptotic pathways and PS externalization.

References

  1. Dumont, E.A. et al. Real time imaging of apoptotic cell membrane changes at the single cell level in the beating murine heart. Nature Med. 7, 1352–1355 (2001).

    Article  CAS  Google Scholar 

  2. Narula, J. et al. Annexin V imaging for noninvasive detection of cardiac allograft rejection. Nature Med. 7, 1347–1352 (2001).

    Article  CAS  Google Scholar 

  3. Vermes, I., Haanen, C. & Reutelingsperger, C. Flow cytometry of apoptotic cell death. J. Immunol. Methods 243, 167–190 (2000).

    Article  CAS  Google Scholar 

  4. Gottlieb, R.A., Burleson, K.O., Kloner, R.A., Babior, B.M. & Engler, R.L. Reperfusion injury induces apoptosis in rabbit cardiomyocytes. J. Clin. Invest. 94, 1621–1628 (1994).

    Article  CAS  Google Scholar 

  5. Yaoita, H., Ogawa, K., Maehara, K. & Maruyama, Y. Attenuation of ischemia/reperfusion injury in rats by a caspase inhibitor. Circulation 97, 276–281 (1998).

    Article  CAS  Google Scholar 

  6. Miao, W., Luo, Z., Kitsis, R.N. & Walsh, K. Intracoronary, adenovirus-mediated Akt gene transfer in heart limits infarct size following ischemia-reperfusion injury in vivo. J. Mol. Cell. Cardiol. 32, 2397–2402 (2000).

    Article  CAS  Google Scholar 

  7. Wencker, D. et al. Rescue of dilated cardiomyopathy by caspase inhibition in FKBP-caspase-8 transgenic mice. Circulation 102 (Supp.), II–28 (2000).

    Google Scholar 

  8. Dumont, E.A. et al. Cardiomyocyte death induced by myocardial ischemia and reperfusion: measurement with recombinant human annexin-V in a mouse model. Circulation 102, 1564–1568 (2000).

    Article  CAS  Google Scholar 

  9. Hofstra, L. et al. Visualisation of cell death in vivo in patients with acute myocardial infarction. Lancet 356, 209–212 (2000).

    Article  CAS  Google Scholar 

  10. Blankenberg, F.G. et al. In vivo detection and imaging of phosphatidylserine expression during programmed cell death. Proc. Natl. Acad. Sci. USA 95, 6349–6354 (1998).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, USA

    Roberta A. Gottlieb

  2. Departments of Medicine (Cardiology) and Cell Biology, Albert Einstein College of Medicine, Bronx, New York, USA

    Richard N. Kitsis

Authors
  1. Roberta A. Gottlieb
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Richard N. Kitsis
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gottlieb, R., Kitsis, R. Seeing death in the living. Nat Med 7, 1277–1278 (2001). https://doi.org/10.1038/nm1201-1277

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm1201-1277

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing