Multiple models have been proposed for the mechanism by which mutant superoxide dismutase 1 induces motor neuron death and amyotrophic lateral sclerosis. A combination of cell biology and genetics may soon lead to an answer.
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Cleveland, D., Liu, J. Oxidation versus aggregation — how do SOD1 mutants cause ALS?. Nat Med 6, 1320–1321 (2000). https://doi.org/10.1038/82122
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DOI: https://doi.org/10.1038/82122
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