Disruption of the gene encoding the cholesterol modifying enzyme ACAT2 in mice leads to a reduced capacity to absorb cholesterol and resistance to diet-induced hypercholesterolemia. This suggests that ACAT2 may be a good target for prevention of atherosclerosis. (pages 1341–1347)
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References
Anitschkow, N. Über die atherosclerose der aorta beim kaninchen and überderin entstehungsbedingungen. Beitraege zur pathologischen Anatomie und zur allgemeinen Pathologie 59, 308–348 (1914).
Smith, E.B. The relationship between plasma and tissue lipids in human atherosclerosis. Adv. Lipid Res. 12, 1–49 (1974).
Chang, C.C.Y., Huh, H.Y., Cadigan, K.M. & Chang, T.Y. Molecular cloning and functional expression of human acyl-coenzyme A:cholesterol acyltransferase cDNA in mutant Chinese hamster ovary cells. J. Biol. Chem. 268, 20747–20755 (1993).
Anderson, R.A. et al. Identification of a form of acyl-CoA:cholesterol acyltransferase specific to liver and intestine in nonhuman primates. J. Biol. Chem. 273, 26747–26754 (1998).
Cases, S. et al. Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis. Proc. Natl. Acad. Sci. USA 95, 13018–13023 (1998).
Cases, S. et al. ACAT-2, A second mammalian acyl-CoA:cholesterol acyltransferase. Its cloning, expression, and characterization. J. Biol. Chem. 273, 26755–26764 (1998).
Oelkers, P., Behari, A., Cromley, D., Billheimer, J.T. & Sturley, S.L. Characterization of two human genes encoding acyl coenzyme A:cholesterol acyltransferase-related enzymes. J. Biol. Chem. 273, 26765–26771 (1998).
Buhman, K. K., et al. Resistance to diet-induced hypercholesterolemia and gallstone formation in ACAT2-deficient mice. Nature Med. 6, 1341–1347 (2000).
Chang, C.C.Y. et al. Immunological quantitation and localization of ACAT-1 and ACAT-2 in human liver and small intestine. J. Biol. Chem. 275, 28083–28092 (2000).
Oram, J.F. & Vaughan, A.M. ABCA1-mediated transport of cellular cholesterol and phospholipids to HDL apolipoproteins. Curr. Opin. Lipidol. 11, 253–260 (2000).
Williams, D.L. et al. Scavenger receptor BI and cholesterol trafficking. Curr. Opin. Lipidol. 10, 329–339 (1999).
Huggins, K.W., Burleson, E.R., Sawyer, J.K., Kelly, K. & Rudel, L.L. Determination of the tissue sites responsible for the catabolism of large high density lipoprotein in the African green monkey. J. Lipid Res. 41, 384–394 (2000).
Klein, R.L. and Rudel, L.L. Cholesterol absorption and transport in thoracic duct lymph lipoproteins of nonhuman primates. Effect of dietary cholesterol level. J. Lipid Res. 24, 343–356 (1983).
Goodman, D.S. The metabolism of chylomicron cholesteryl ester in the rat. J. Clin. Invest. 41, 1886–1896 (1962).
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Rudel, L., Shelness, G. Cholesterol esters and atherosclerosis–a game of ACAT and mouse. Nat Med 6, 1313–1314 (2000). https://doi.org/10.1038/82110
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DOI: https://doi.org/10.1038/82110
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