Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Between Bedside and Bench
  • Published:

Graft-versus-host disease: suppression by statins

Nature Medicine volume 14, pages 1155–1156 (2008)Cite this article

Two big challenges of transplantation biology are controlling the reaction of the graft to the host after hematopoietic stem cell transplantation and preventing rejection of donor organs by the host. Raewyn Broady and Megan K. Levings discuss the first challenge, examining studies suggesting that statins might be helpful to control graft-versus-host disease. Kathryn Wood tackles the second challenge in the context of the 'Edmonton protocol', a procedure that can restore the ability to control blood glucose in people with type 1 diabetes—but only in the short term.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Statins could alter the balance of CD4+ TH cell subsets and reduce GVHD.

References

  1. Welniak, L.A., Blazar, B.R. & Murphy, W.J. Annu. Rev. Immunol. 25, 139–170 (2007).

    Article  CAS  Google Scholar 

  2. Zeiser, R. et al. Blood 110, 4588–4598 (2007).

    Article  CAS  Google Scholar 

  3. Hamadani, M., Awan, F.T. & Devine, S.M. Blood 111, 3901–3902 (2008).

    Article  CAS  Google Scholar 

  4. Liao, J.K. & Laufs, U. Annu. Rev. Pharmacol. Toxicol. 45, 89–118 (2005).

    Article  CAS  Google Scholar 

  5. Allan, S.E. et al. Immunol. Rev. 223, 391–421 (2008).

    Article  CAS  Google Scholar 

  6. Greenwood, J., Steinman, L. & Zamvil, S.S. Nat. Rev. Immunol. 6, 358–370 (2006).

    Article  CAS  Google Scholar 

  7. Mausner-Fainberg, K. et al. Atherosclerosis 197, 829–839 (2008).

    Article  CAS  Google Scholar 

  8. Mira, E. et al. J. Immunol. 181, 3524–3534 (2008).

    Article  CAS  Google Scholar 

  9. Chen, X. et al. Blood 110, 3804–3813 (2007).

    Article  CAS  Google Scholar 

  10. Zhang, X., Jin, J., Peng, X., Ramgolam, V.S. & Markovic-Plese, S. J. Immunol. 180, 6988–6996 (2008).

    Article  CAS  Google Scholar 

  11. Hori, A. et al. Transplantation 79, 372–374 (2005).

    Article  CAS  Google Scholar 

  12. Mason, R.P., Walter, M.F., Day, C.A. & Jacob, R.F. Am. J. Cardiol. 96, 11F–23F (2005).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Raewyn Broady is in the Department of Medicine and Megan K. Levings is in the Department of Surgery, University of British Columbia and Immunity and Infection Research Centre, Vancouver Coastal Health Research Institute. 2660 Oak Street, Vancouver, V6H 3Z6 British Columbia, Canada. mlevings@interchange.ubc.ca,

    Raewyn Broady & Megan K Levings

Authors
  1. Raewyn Broady
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Megan K Levings
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Broady, R., Levings, M. Graft-versus-host disease: suppression by statins. Nat Med 14, 1155–1156 (2008). https://doi.org/10.1038/nm1108-1155

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm1108-1155

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing